Biodegradation of polymer compounds based on cross-linked dextrans

被引：6

作者：

Gumargalieva, KZ ^{[1
]}

Shipunova, OV ^{[1
]}

Zaikov, GE ^{[1
]}

Jubanov, BA ^{[1
]}

Moshkevitch, SA ^{[1
]}

机构：

[1] KAZAKH ACAD SCI,INST CHEM SCI,ALMA ATA 480021,KAZAKHSTAN

来源：

POLYMER DEGRADATION AND STABILITY | 1996年 / 51卷 / 01期

关键词：

D O I：

10.1016/0141-3910(95)00162-X

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

It is shown that cross-linked dextrans can be the basis for obtaining a drug reservoir which is a physiologically active polymer with the drug grafted to the matrix by chemical links. A drug form for treatment of tuberculosis has been obtained. The kinetics of drug release into model media and blood plasma has been investigated. It is found that polymeric derivatives of isonyazide and kanamycin can be applied for the development of drug reservoirs with lower rate of release over a long period of time.

引用

页码：57 / 65

页数：9

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