Molecular epidemiology of tuberculosis in Turkey

被引:18
作者
Durmaz, R [1 ]
Gunal, S
Yang, Z
Ozerol, IH
Cave, MD
机构
[1] Inonu Univ, Fac Med, Dept Clin Microbiol, TR-44069 Malatya, Turkey
[2] Cent Arkansas Vet Hlth Serv Ctr, Mycobacteriol Res Lab, Little Rock, AR USA
关键词
tuberculosis; Mycobacterium tuberculosis; IS6110; molecular epidemiology;
D O I
10.1046/j.1469-0691.2003.00654.x
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Our objective was to determine the extent of fingerprint pattern diversity of Mycobacterium tuberculosis isolates from Turkey. Of the 320 patient isolates, 81 (25.3%) carried less than or equal to5 copies of IS6110. The combination of two typing procedures on isolates from 317 patients identified 157 strains as unique and clustered 160 isolates in 59 clusters. In spite of the fact that the patients originated from a large geographic area and represented only a small fraction (1.5%) of the patients in the country, 50.5% of the isolates were clustered.
引用
收藏
页码:873 / 877
页数:5
相关论文
共 12 条
[1]   Usefulness of spoligotyping to discriminate IS6110 low-copy-number Mycobacterium tuberculosis complex strains cultured in Denmark [J].
Bauer, J ;
Andersen, ÅB ;
Kremer, K ;
Miörner, H .
JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (08) :2602-2606
[2]   Usefulness of the secondary probe pTBN12 in DNA fingerprinting of Mycobacterium tuberculosis [J].
Chaves, F ;
Yang, ZH ;
ElHajj, H ;
Alonso, M ;
Burman, WJ ;
Eisenach, KD ;
Dronda, F ;
Bates, JH ;
Cave, MD .
JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (05) :1118-1123
[3]  
Gutiérrez MC, 1998, J CLIN MICROBIOL, V36, P486
[4]   Molecular fingerprinting of Mycobacterium tuberculosis isolates obtained in Havana, Cuba, by IS6110 restriction fragment length polymorphism analysis and by the double-repetitive-element PCR method [J].
Montoro, E ;
Valdivia, J ;
Leao, SC .
JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (10) :3099-3102
[5]   THE EPIDEMIOLOGY OF TUBERCULOSIS IN SAN-FRANCISCO - A POPULATION-BASED STUDY USING CONVENTIONAL AND MOLECULAR METHODS [J].
SMALL, PM ;
HOPEWELL, PC ;
SINGH, SP ;
PAZ, A ;
PARSONNET, J ;
RUSTON, DC ;
SCHECTER, GF ;
DALEY, CL ;
SCHOOLNIK, GK .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (24) :1703-1709
[6]   CHROMOSOMAL DNA-FINGERPRINTING ANALYSIS USING THE INSERTION-SEQUENCE IS6110 AND THE REPETITIVE ELEMENT DR AS STRAIN-SPECIFIC MARKERS FOR EPIDEMIOLOGIC-STUDY OF TUBERCULOSIS IN FRENCH-POLYNESIA [J].
TORREA, G ;
LEVEE, G ;
GRIMONT, P ;
MARTIN, C ;
CHANTEAU, S ;
GICQUEL, B .
JOURNAL OF CLINICAL MICROBIOLOGY, 1995, 33 (07) :1899-1904
[7]   STRAIN IDENTIFICATION OF MYCOBACTERIUM-TUBERCULOSIS BY DNA FINGERPRINTING - RECOMMENDATIONS FOR A STANDARDIZED METHODOLOGY [J].
VANEMBDEN, JDA ;
CAVE, MD ;
CRAWFORD, JT ;
DALE, JW ;
EISENACH, KD ;
GICQUEL, B ;
HERMANS, P ;
MARTIN, C ;
MCADAM, R ;
SHINNICK, TM ;
SMALL, PM .
JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (02) :406-409
[8]   PREDOMINANCE OF A SINGLE GENOTYPE OF MYCOBACTERIUM-TUBERCULOSIS IN COUNTRIES OF EAST-ASIA [J].
VANSOOLINGEN, D ;
QIAN, LS ;
DEHAAS, PEW ;
DOUGLAS, JT ;
TRAORE, H ;
PORTAELS, F ;
QING, HZ ;
ENKHSAIKAN, D ;
NYMADAWA, P ;
VANEMBDEN, JDA .
JOURNAL OF CLINICAL MICROBIOLOGY, 1995, 33 (12) :3234-3238
[9]   OCCURRENCE AND STABILITY OF INSERTION SEQUENCES IN MYCOBACTERIUM-TUBERCULOSIS COMPLEX STRAINS - EVALUATION OF AN INSERTION SEQUENCE-DEPENDENT DNA POLYMORPHISM AS A TOOL IN THE EPIDEMIOLOGY OF TUBERCULOSIS [J].
VANSOOLINGEN, D ;
HERMANS, PWM ;
DEHAAS, PEW ;
SOLL, DR ;
VANEMBDEN, JDA .
JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (11) :2578-2586
[10]   Molecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in rural Africa [J].
Wilkinson, D ;
Pillay, M ;
Crump, J ;
Lombard, C ;
Davies, GR ;
Sturm, AW .
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 1997, 2 (08) :747-753