Growth factor-dependent signaling and cell cycle progression

被引:89
作者
Jones, SM [1 ]
Kazlauskas, A [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Ophthalmol, Schepens Eye Res Inst, Boston, MA 02114 USA
关键词
PDGF; cell cycle progression; signal transduction;
D O I
10.1016/S0014-5793(01)02113-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There are three central ideas contained within this review. Firstly, growth factor-stimulated signaling is not restricted to a 30-60 min window, but occurs at a much later time as well. Secondly, the second wave of signaling overlaps temporally with the cell cycle program and may be directly responsible for engaging it. Thirdly, the G1 to S interval appears to encompass two distinct phases of the cell cycle, during which the coordinated activation of distinct sets of signaling enzymes drives cell cycle progression. Each of these concepts is likely to initiate new investigation and hence provide additional insight into the fundamental question of how growth factors drive cell proliferation. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:110 / 116
页数:7
相关论文
共 63 条
  • [1] Agrawal D, 1996, MOL CELL BIOL, V16, P4327
  • [2] Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27(KIP1)
    Aktas, H
    Cai, H
    Cooper, GM
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (07) : 3850 - 3857
  • [3] TRANSFORMING P21(RAS) MUTANTS AND C-ETS-2 ACTIVATE THE CYCLIN D1 PROMOTER THROUGH DISTINGUISHABLE REGIONS
    ALBANESE, C
    JOHNSON, J
    WATANABE, G
    EKLUND, N
    VU, D
    ARNOLD, A
    PESTELL, RG
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (40) : 23589 - 23597
  • [4] PDGF-DEPENDENT TYROSINE PHOSPHORYLATION STIMULATES PRODUCTION OF NOVEL POLYPHOSPHOINOSITIDES IN INTACT-CELLS
    AUGER, KR
    SERUNIAN, LA
    SOLTOFF, SP
    LIBBY, P
    CANTLEY, LC
    [J]. CELL, 1989, 57 (01) : 167 - 175
  • [5] PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition
    Balciunaite, E
    Jones, S
    Toker, A
    Kazlauskas, A
    [J]. CURRENT BIOLOGY, 2000, 10 (05) : 261 - 267
  • [6] Bennett AM, 1996, MOL CELL BIOL, V16, P1189
  • [7] Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
    Brunet, A
    Bonni, A
    Zigmond, MJ
    Lin, MZ
    Juo, P
    Hu, LS
    Anderson, MJ
    Arden, KC
    Blenis, J
    Greenberg, ME
    [J]. CELL, 1999, 96 (06) : 857 - 868
  • [8] New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase AKT pathway
    Cantley, LC
    Neel, BG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (08) : 4240 - 4245
  • [9] The p21Cip1 and p27Kip1 CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
    Cheng, MG
    Olivier, P
    Diehl, JA
    Fero, M
    Roussel, MF
    Roberts, JM
    Sherr, CJ
    [J]. EMBO JOURNAL, 1999, 18 (06) : 1571 - 1583
  • [10] Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
    Cheng, MG
    Sexl, V
    Sherr, CJ
    Roussel, MF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (03) : 1091 - 1096