The function of herpes simplex virus genes: A primer for genetic engineering of novel vectors

被引：176

作者：

Roizman, B

机构：

[1] Marjorie B. Kovler Viral Oncol. L., University of Chicago, Chicago, IL 60637

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 21期

关键词：

D O I：

10.1073/pnas.93.21.11307

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Herpes simplex virus vectors are being developed for delivery and expression of human genes to the central nervous system, selective destruction of cancer cells, and as carriers for genes encoding antigens that induce protective immunity against infectious agents. Vectors constructed to meet these objectives must differ from wild-type virus with respect to host range, reactivation from latency, and expression of viral genes. The vectors currently being developed are (i) helper free amplicons, (ii) replication defective viruses, and (iii) genetically engineered replication competent viruses with restricted host range. Whereas the former two types of vectors require stable, continuous cell lines expressing viral genes for their replication, the replication competent viruses will replicate on approved primary human cell strains.

引用

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页码：11307 / 11312

页数：6

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共 45 条

[1] The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors [J].

Andreansky, SS ;

He, B ;

Gillespie, GY ;

Soroceanu, L ;

Markert, J ;

Chou, J ;

Roizman, B ;

Whitley, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :11313-11318

[2] TRANSCRIPTIONAL ANALYSIS OF THE REGION OF THE HERPES-SIMPLEX VIRUS TYPE-1 GENOME CONTAINING THE UL8, UL9, AND UL10 GENES AND IDENTIFICATION OF A NOVEL DELAYED-EARLY GENE-PRODUCT, OBPC [J].

BARADARAN, K ;

DABROWSKI, CE ;

SCHAFFER, PA .

JOURNAL OF VIROLOGY, 1994, 68 (07) :4251-4261

[3] THE UNIQUE SEQUENCE OF THE HERPES-SIMPLEX VIRUS-1 L COMPONENT CONTAINS AN ADDITIONAL TRANSLATED OPEN READING FRAME DESIGNATED UL49.5 [J].

BARKER, DE ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1992, 66 (01) :562-566

[4] CHARACTERIZATION OF THE HERPES-SIMPLEX VIRION-ASSOCIATED FACTOR RESPONSIBLE FOR THE INDUCTION OF ALPHA-GENES [J].

BATTERSON, W ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1983, 46 (02) :371-377

[5] Open reading frame P - A herpes simplex virus gene repressed during productive infection encodes a protein that binds a splicing factor and reduces synthesis of viral proteins made from spliced mRNA [J].

Bruni, R ;

Roizman, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10423-10427

[6] The promoter and transcriptional unit of a novel herpes simplex virus 1 alpha gene are contained in, and encode a protein in frame with, the open reading frame of the alpha 22 gene [J].

Carter, KL ;

Roizman, B .

JOURNAL OF VIROLOGY, 1996, 70 (01) :172-178

[7] THE TERMINAL-A SEQUENCE OF THE HERPES-SIMPLEX VIRUS GENOME CONTAINS THE PROMOTER OF A GENE LOCATED IN THE REPEAT SEQUENCES OF THE L-COMPONENT [J].

CHOU, J ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1986, 57 (02) :629-637

[8] MAPPING OF HERPES-SIMPLEX VIRUS-1 NEUROVIRULENCE TO GAMMA-134.5, A GENE NONESSENTIAL FOR GROWTH IN CULTURE [J].

CHOU, J ;

KERN, ER ;

WHITLEY, RJ ;

ROIZMAN, B .

SCIENCE, 1990, 250 (4985) :1262-1266

[9] ASSOCIATION OF A M(R)-90,000 PHOSPHOPROTEIN WITH PROTEIN-KINASE PKR IN CELLS EXHIBITING ENHANCED PHOSPHORYLATION OF TRANSLATION INITIATION-FACTOR EIF-2-ALPHA AND PREMATURE SHUTOFF OF PROTEIN-SYNTHESIS AFTER INFECTION WITH GAMMA(1)34.5(-) MUTANTS OF HERPES-SIMPLEX-VIRUS-1 [J].

CHOU, J ;

CHEN, JJ ;

GROSS, M ;

ROIZMAN, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) :10516-10520

[10]

FRAEFEL C, 1996, IN PRESS J VIROL

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