The ups and downs of miR-205 Identifying the roles of miR-205 in mammary gland development and breast cancer

被引：103

作者：

Greene, Stephanie B. ^{[1
]}

Herschkowitz, Jason I. ^{[2
]}

Rosen, Jeffrey M. ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

RNA BIOLOGY | 2010年 / 7卷 / 03期

关键词：

miR-205; breast cancer; mammary gland development; stem cells; MICRORNA EXPRESSION; PROSTATE; PROTEIN; TUMORS; RNA;

D O I：

10.4161/rna.7.3.11837

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of its regulation and targets. Additionally, miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. The role that miR-205 plays in tumor formation and metastasis is likely context-dependent as reports have indicated that it may function as either a tumor suppressor or an oncogene. The role that miR-205 plays in directing stem cell fate is still unknown.

引用

页码：300 / 304

页数：5

共 40 条

[1]

Characterisation of microRNA expression in post-natal mouse mammary gland development [J].

Avril-Sassen, Stefanie ;

Goldstein, Leonard D. ;

Stingl, John ;

Blenkiron, Cherie ;

Le Quesne, John ;

Spiteri, Inmaculada ;

Karagavriilidou, Konstantina ;

Watson, Christine J. ;

Tavare, Simon ;

Miska, Eric A. ;

Caldas, Carlos .

BMC GENOMICS, 2009, 10

[2]

MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets [J].

Baffa, Raffaele ;

Fassan, Matteo ;

Volinia, Stefano ;

O'Hara, Brian ;

Liu, Chang-Gong ;

Palazzo, Juan P. ;

Gardiman, Marina ;

Rugge, Massimo ;

Gomella, Leonard G. ;

Croce, Carlo M. ;

Rosenberg, Anne .

JOURNAL OF PATHOLOGY, 2009, 219 (02) :214-221

[3]

Accurate Classification of Non-Small Cell Lung Carcinoma Using a Novel MicroRNA-Based Approach [J].

Bishop, Justin A. ;

Benjamin, Hila ;

Cholakh, Hila ;

Chajut, Ayelet ;

Clark, Douglas P. ;

Westra, William H. .

CLINICAL CANCER RESEARCH, 2010, 16 (02) :610-619

[4]

MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype [J].

Blenkiron, Cherie ;

Goldstein, Leonard D. ;

Thorne, Natalie P. ;

Spiteri, Inmaculada ;

Chin, Suet-Feung ;

Dunning, Mark J. ;

Barbosa-Morais, Nuno L. ;

Teschendorff, Andrew E. ;

Green, Andrew R. ;

Ellis, Ian O. ;

Tavare, Simon ;

Caldas, Carlos ;

Miska, Eric A. .

GENOME BIOLOGY, 2007, 8 (10)

[5]

MicroRNAs modulate hematopoietic lineage differentiation [J].

Chen, CZ ;

Li, L ;

Lodish, HF ;

Bartel, DP .

SCIENCE, 2004, 303 (5654) :83-86

[6]

The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation [J].

Chen, JF ;

Mandel, EM ;

Thomson, JM ;

Wu, QL ;

Callis, TE ;

Hammond, SM ;

Conlon, FL ;

Wang, DZ .

NATURE GENETICS, 2006, 38 (02) :228-233

[7]

Low-Level Expression of MicroRNAs let-7d and miR-205 Are Prognostic Markers of Head and Neck Squamous Cell Carcinoma [J].

Childs, Geoffrey ;

Fazzari, Melissa ;

Kung, Gloria ;

Kawachi, Nicole ;

Brandwein-Gensler, Margaret ;

McLemore, Michael ;

Chen, Quan ;

Burk, Robert D. ;

Smith, Richard V. ;

Prystowsky, Michael B. ;

Belbin, Thomas J. ;

Schlecht, Nicolas F. .

AMERICAN JOURNAL OF PATHOLOGY, 2009, 174 (03) :736-745

[8]

MicroRNA expression during chick embryo development [J].

Darnell, Diana K. ;

Kaur, Simran ;

Stanislaw, Stacey ;

Konieczka, Jay K. ;

Yatskievych, Tatiana A. ;

Antin, Parker B. .

DEVELOPMENTAL DYNAMICS, 2006, 235 (11) :3156-3165

[9]

Accumulation of miR-155 and BIC RNA in human B cell lymphomas [J].

Eis, PS ;

Tam, W ;

Sun, LP ;

Chadburn, A ;

Li, ZD ;

Gomez, MF ;

Lund, E ;

Dahlberg, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (10) :3627-3632

[10]

Detection of Metastatic Head and Neck Squamous Cell Carcinoma Using the Relative Expression of Tissue-Specific Mir-205 [J].

Fletcher, Aaron M. ;

Heaford, Andrew C. ;

Trask, Douglas K. .

TRANSLATIONAL ONCOLOGY, 2008, 1 (04) :202-209

← 1 2 3 4 →