PAPP-A: a new anti-aging target?

被引：27

作者：

Conover, Cheryl A. ^{[1
]}

机构：

[1] Mayo Clin, Div Endocrinol Metab & Nutr, Endocrine Res Unit, Rochester, MN 55905 USA

来源：

AGING CELL | 2010年 / 9卷 / 06期

基金：

美国国家卫生研究院;

关键词：

insulin-like growth factor; longevity; PAPP-A knock-out mice; pregnancy-associated plasma protein-A; PLASMA-PROTEIN-A; FACTOR-BINDING PROTEIN-4; LONG-LIVED MICE; GROWTH-FACTOR-I; PROTEOLYTIC ACTIVITY; HUMAN FIBROBLASTS; IGF; EXPRESSION; DEFICIENT; CELLS;

D O I：

10.1111/j.1474-9726.2010.00630.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

P>This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.

引用

页码：942 / 946

页数：5

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