Toward precision medicine in primary biliary cholangitis

被引：15

作者：

Carbone, Marco ^{[1
,2
,3
]}

Ronca, Vincenzo ^{[3
]}

Bruno, Savino ^{[3
]}

Invernizzi, Pietro ^{[4
]}

Mells, George F. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Acad Dept Med Genet, Cambridge, England

[2] Univ Cambridge, MRC Epidemiol Unit, Cambridge, England

[3] Humanitas Clin & Res Inst, Liver Unit, Milan, Italy

[4] Univ Milano Bicocca, Dept Med & Surg, Int Ctr Digest Hlth, Program Autoimmune Liver Dis, Milan, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2016年 / 48卷 / 08期

关键词：

Primary biliary cholangitis; Precision medicine; Risk-stratification; HEPATITIS OVERLAP SYNDROME; URSODEOXYCHOLIC ACID; BIOCHEMICAL RESPONSE; CHANGING NOMENCLATURE; AUTOIMMUNE HEPATITIS; ANTICENTROMERE ANTIBODIES; ANTINUCLEAR ANTIBODIES; CLINICAL-SIGNIFICANCE; RISK-FACTORS; CIRRHOSIS;

D O I：

10.1016/j.dld.2016.05.023

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Primary biliary cholangitis is a chronic, cholestatic liver disease characterized by a heterogeneous presentation, symptomatology, disease progression and response to therapy. In contrast, clinical management and treatment of PBC is homogeneous with a 'one size fits all' approach. The evolving research landscape, with the emergence of the -omics field and the availability of large patient cohorts are creating a unique opportunity of translational epidemiology. Furthermore, several novel disease and symptom-modifying agents for PBC are currently in development. The time is therefore ripe for precision medicine in PBC. In this manuscript we describe the concept of precision medicine; review current approaches to risk-stratification in PBC, and speculate how precision medicine in PBC might develop in the near future. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：843 / 850

页数：8

共 40 条

[1]

Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis' [J].

Beuers, Ulrich ;

Gershwin, M. Eric ;

Gish, Robert G. ;

Invernizzi, Pietro ;

Jones, David E. J. ;

Lindor, Keith ;

Ma, Xiong ;

Mackay, Ian R. ;

Pares, Albert ;

Tanaka, Atsushi ;

Vierling, John M. ;

Poupon, Raoul .

GASTROENTEROLOGY, 2015, 149 (06) :1627-1629

[2]

Changing nomenclature for PBC: From "cirrhosis' to "cholangitis' [J].

Beuers, Ulrich ;

Gershwin, M. Eric ;

Gish, Robert G. ;

Invernizzi, Pietro ;

Jones, David E. J. ;

Lindor, Keith ;

Ma, Xiong ;

Mackay, Ian R. ;

Pares, Albert ;

Tanaka, Atsushi ;

Vierling, John M. ;

Poupon, Raoul .

HEPATOLOGY, 2015, 62 (05) :1620-1622

[3]

Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis' [J].

Beuers, Ulrich ;

Gershwin, M. Eric ;

Gish, Robert G. ;

Invernizzi, Pietro ;

Jones, David E. J. ;

Lindor, Keith ;

Ma, Xiong ;

Mackay, Ian R. ;

Pares, Albert ;

Tanaka, Atsushi ;

Vierling, John M. ;

Poupon, Raoul .

GUT, 2015, 64 (11) :1671-1672

[4]

EASL Clinical Practice Guidelines: Management of cholestatic liver diseases [J].

Beuers, Ulrich ;

Boberg, Kirsten M. ;

Chapman, Roger W. ;

Chazouilleres, Olivier ;

Invernizzi, Pietro ;

Jones, David E. J. ;

Lammert, Frank ;

Pares, Albert ;

Trauner, Michael .

JOURNAL OF HEPATOLOGY, 2009, 51 (02) :237-267

[5]

Identification of major linear epitopes on the sp100 nuclear PBC antoantigen by the gene-fragment phage-display technology [J].

Blüthner, M ;

Schäfer, C ;

Schneider, C ;

Bautz, FA .

AUTOIMMUNITY, 1999, 29 (01) :33-42

[6]

Bota S., Liver Int

[7]

Branzen K., 2013, PERSONALIZED MED NEW

[8]

The UK-PBC Risk Scores: Derivation and Validation of a Scoring System for Long-Term Prediction of End-Stage Liver Disease in Primary Biliary Cholangitis [J].

Carbone, Marco ;

Sharp, Stephen J. ;

Flack, Steve ;

Paximadas, Dimitrios ;

Spiess, Kelly ;

Adgey, Carolyn ;

Griffiths, Laura ;

Lim, Reyna ;

Trembling, Paul ;

Williamson, Kate ;

Wareham, Nick J. ;

Aldersley, Mark ;

Bathgate, Andrew ;

Burroughs, Andrew K. ;

Heneghan, Michael A. ;

Neuberger, James M. ;

Thorburn, Douglas ;

Hirschfield, Gideon M. ;

Cordell, Heather J. ;

Alexander, Graeme J. ;

Jones, David E. J. ;

Sandford, Richard N. ;

Mells, George F. .

HEPATOLOGY, 2016, 63 (03) :930-950

[9]

Autoimmune liver disease, autoimmunity and liver transplantation [J].

Carbone, Marco ;

Neuberger, James M. .

JOURNAL OF HEPATOLOGY, 2014, 60 (01) :210-223

[10]

Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid [J].

Carbone, Marco ;

Mells, George F. ;

Pells, Greta ;

Dawwas, Muhammad F. ;

Newton, Julia L. ;

Heneghan, Michael A. ;

Neuberger, James M. ;

Day, Darren B. ;

Ducker, Samantha J. ;

Sandford, Richard N. ;

Alexander, Graeme J. ;

Jones, David E. J. .

GASTROENTEROLOGY, 2013, 144 (03) :560-+

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