Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

被引：112

作者：

Xu, Ziqiang ^{[2
]}

Li, Man ^{[2
]}

Li, Xia ^{[2
]}

Liu, Xiangmei ^{[2
]}

Ma, Fei ^{[1
]}

Wu, Shuilin ^{[2
]}

Yeung, K. W. K. ^{[3
]}

Han, Yong ^{[1
]}

Chu, Paul K. ^{[4
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Mech Behav Mat, Xian 710049, Shaanxi, Peoples R China

[2] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Minist Educ,Sch Mat Sci & Engn, Key Lab Green Preparat & Applicat Funct Mat,Hubei, Wuhan 430062, Peoples R China

[3] Univ Hong Kong, Li KaShing Fac Med, Div Spine Surg, Dept Orthopaed & Traumatol, Hong Kong 999077, Hong Kong, Peoples R China

[4] City Univ Hong Kong, Dept Phys Mat Sci, Tat Chee Ave, Kowloon 999077, Hong Kong, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2016年 / 8卷 / 26期

基金：

中国国家自然科学基金;

关键词：

nanostructured film; nanowire; Ag nanoparticle; antibacterial; titanium; implant; STAPHYLOCOCCUS-AUREUS; BACTERIAL ADHESION; TITANIUM SURFACES; HYDROXYAPATITE COATINGS; OSTEOBLAST FUNCTIONS; ORTHOPEDIC IMPLANTS; NANOPARTICLES; NANOTUBES; METAL; ALLOY;

D O I：

10.1021/acsami.6b04161

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the surface antibacterial activity and biocompatibility of titanium implants. A TNWs film was produced on a Ti substrate by an alkali hydrothermal reaction and subsequently doped by Ag nanoparticles through an ultraviolet light chemical reduction. The CS nanofilm was deposited on the Ag nanoparticles through a spin-assisted layer by layer assembly method. The results disclosed that Ag nanoparticles were successfully carried by TNWs and homogeneously distributed on the entire surface. Moreover, a CS nanofilm was also successfully deposited on the Ag nanoparticles. Antibacterial tests showed that the samples modified with a higher initial concentration of AgNO3 solution exhibited better antibacterial activity, and that a CS nanofilm could further improve the antibacterial activity of the TNWs. Cell viability and ALP tests revealed that the release of Ag+ was detrimental for the growth, proliferation, and differentiation of MC3T3, and that CS could lower the negative effects of Ag gradually as the incubation time increased.

引用

页码：16584 / 16594

页数：11

共 59 条

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