Isolation, structure elucidation and biological activities of trichofumins A, B, C and D, new 11 and 13mer peptaibols from Trichoderma sp HKI 0276

被引：27

作者：

Berg, A

Grigoriev, PA

Degenkolb, T

Neuhof, T

Härtl, A

Schlegel, B

Gräfe, L

机构：

[1] Hans Knoll Inst Nat Prod Res, D-07745 Jena, Germany

[2] Russian Acad Sci, Inst Cell Biophys, Pushchino 142290, Moscow Reg, Russia

[3] Inst Plant Biochem, D-06120 Halle Saale, Germany

[4] Anagnostec GmbH, D-14943 Luckenwalde, Germany

来源：

JOURNAL OF PEPTIDE SCIENCE | 2003年 / 9卷 / 11-12期

关键词：

trichofumins; 11 and 13mer peptaibols; structure elucidation; effects on fungal morphogenesis; pigment formation; membrane activity;

D O I：

10.1002/psc.498

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trichofumins A-D were isolated from cultures of Trichoderma sp. HKI 0276 as new 11 and 13mer peptaibols. Similar to 15mer peptaibols they promote morphogenesis of the fungus Phoma destructiva and cause hypothermia in mice as a characteristic of neuroleptic activity. Membrane measurements using a synthetic BLM model showed that A, B, C and D increased membrane permeability for cations in a similar manner as was shown for larger peptaibols but with comparably lower efficiency. Copyright (C) 2003 European Peptide Society and John Wiley Sons, Ltd.

引用

页码：810 / 816

页数：7

共 18 条

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