Gα12 and Gα13 as key regulatory mediator in signal transduction

被引：78

作者：

Kurose, H ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol & Toxicol, Higashi Ku, Fukuoka 8128582, Japan

来源：

LIFE SCIENCES | 2003年 / 74卷 / 2-3期

关键词：

G(12) family G protein; G alpha(12) and G alpha(13); guanine nucleotide exchange factor; interacting proteins;

D O I：

10.1016/j.lfs.2003.09.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It is generally thought that Galpha(12) and Galpha(13)-induced responses are exclusively mediated by small G protein Rho. However, Galpha(12) and Galpha(13) elicit divergent cellular responses: phospholipase C-epsilon activation, phospholipase D activation, cytoskeletal. change, oncogenic response, apoptosis, MAP kinase activation and Na/H-exchange activation. In addition to Rho activation through RhoGEF, it has been recently demonstrated that Galpha(12) and Galpha(13) interact with several proteins and regulate their activities. However, physiological importance of the interaction of Galpha(12) and Galpha(13) with these proteins has not fully established. I summarize the recent progress of Galpha(12) and Galpha(13)-mediated signaling cascade. (C) 2003 Elsevier Inc. All rights reserved.

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页码：155 / 161

页数：7

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