Antifungal mechanism of polygodial

被引：73

作者：

Kubo, I ^{[1
]}

Fujita, K ^{[1
]}

Lee, SH ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2001年 / 49卷 / 03期

关键词：

antifungal activity; Saccharomyces cerevisiae; polygodial; surfactant property; acidification; H+-ATPase; lipid-protein interface;

D O I：

10.1021/jf000136g

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The primary antifungal action of polygodial comes in part from its ability to function Bs a nonionic surfactant, disrupting the lipid-protein interface of integral proteins and denaturing their conformation. As a result, the antifungal mechanism of this sesquiterpene dialdehyde is associated with the membrane functions or derangement of the:membrane. For example, the glucose-induced medium acidification process of Saccharomyces cerevisiae was inhibited by polygodial presumably caused by inhibition of the plasma membrane H+-ATPase. However, the potent antifungal activity of polygodial results from its multiple functions.

引用

页码：1607 / 1611

页数：5

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