Increased mutation frequencies in Escherichia coli isolates harboring extended-spectrum β-lactamases

被引：30

作者：

Baquero, MR

Galán, JC

Turrientes, MD

Cantón, R

Coque, TM

Martínez, JL

Baquero, F

机构：

[1] Ramon y Cajal Univ Hosp, Dept Microbiol, Madrid 28034, Spain

[2] CSIC, Ctr Nacl Biotecnol, RYC Associated Unit Antibiot Resistance & Bacteri, Madrid 28034, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 11期

关键词：

D O I：

10.1128/AAC.49.11.4754-4756.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hypermutable (mutation frequency [f], >= 4 x 10(-8)) Escherichia coli strains were more frequently found (43%) in a collection of 89 extended-spectrum P-lactamase (ESBL) -producing isolates from different patients (77 pulsed-field gel electrophoresis clones, 12 ESBL types) than in non-ESBL E. coli (26%) strains (P = 0.03). Among urinary tract isolates, the frequency of hypermutation was 40% in ESBL versus 26% in non-ESBL isolates (P = 0.03).

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收藏

页码：4754 / 4756

页数：3

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