Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia

被引：29

作者：

Nian, Yin ^{[1
,2
]}

Wang, Hai-Yan ^{[1
,2
]}

Su, Jia ^{[1
,2
]}

Zhou, Lin ^{[1
]}

Feng, Gang ^{[1
]}

Li, Yan ^{[1
]}

Qiu, Ming-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

TETRAHEDRON | 2012年 / 68卷 / 32期

基金：

中国国家自然科学基金;

关键词：

Cimicifuga heracleifolia; Cycloartane triterpenes; Cytotoxicity; Structure-activity relationships; CELL-CYCLE; CIMISIDE E; CONSTITUENTS; GLYCOSIDES; PROLIFERATION; RANUNCULACEAE; PHYLOGENY; RHIZOMA; ACTAEA; PARTS;

D O I：

10.1016/j.tet.2012.05.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Phytochemical investigation on the roots of Cimicifuga heracleifolia afforded nine new 9,19-cycloartane triterpenes (1-9), along with seven known constituents (10-16). The new structures were elucidated by spectroscopic and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines indicated that eight cimigenol-type compounds (1-3,5, 10-12,14) showed different levels of cytotoxic activities, with IC50 values ranging from 0.83 to 23.94 mu M. In addition, their structural and bioactive features enriched the structure-activity relationships we proposed before. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6521 / 6527

页数：7

共 30 条

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[3]

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