Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation

被引：102

作者：

Johnston, DS

Russell, LD

Friel, PJ

Griswold, MD ^{[1
]}

机构：

[1] Washington State Univ, Sch Mol Biosci, Pullman, WA 99164 USA

[2] Washington State Univ, Ctr Reprod Biol, Pullman, WA 99164 USA

[3] So Illinois Univ, Sch Med, Dept Physiol, Carbondale, IL 62901 USA

来源：

ENDOCRINOLOGY | 2001年 / 142卷 / 06期

关键词：

D O I：

10.1210/en.142.6.2405

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The spermatogonial stem cell transplantation technique was employed to determine if murine germ cells require functional androgen receptors to complete qualitatively normal spermatogenesis. Testicular cells from testicular feminized mice were injected into the seminiferous tubules of azoospermic mice expressing functional androgen receptors. Recipient testes were analyzed between 110 and 200 days following transplantation. Multiple colonies of complete and qualitatively normal donor-derived spermatogenesis were seen within the seminiferous tubules of each recipient testis, demonstrating that murine germ cells do not require functional androgen receptors to complete spermatogenesis.

引用

页码：2405 / 2408

页数：4

共 28 条

[1] ANALYSIS OF THE ANDROGEN RECEPTOR IN ISOLATED TESTICULAR CELL-TYPES WITH A MICROASSAY THAT USES AN AFFINITY LIGAND [J].