Anti-prothrombin antibodies and their relation with thrombosis and lupus anticoagulant

被引:35
作者
de Groot, PG
Horbach, DA
Simmelink, MJA
van Oort, E
Derksen, RHWM
机构
[1] Univ Utrecht, Med Ctr, Dept Haematol, NL-3508 GA Utrecht, Netherlands
[2] Univ Utrecht, Med Ctr, Dept Rheumat & Clin Immunol, NL-3508 GA Utrecht, Netherlands
关键词
antiprothrombin antibodies; antiphospholipid antibodies; protein C; prothrombin; lupus anticoagulant;
D O I
10.1177/096120339800700208
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Antiphospholipid antibodies are a heterogeneous group of antibodies, comprising antibodies with different antigen specificity. Prothrombin is one of the antigens which can be detected by antiphospholipid antibodies and therefore anti-prothrombin antibodies belong to the antiphospholipid antibody family. The presence of antiphospholipid antibodies correlates strongly with thromboembolic complications; however a mechanism by which these autoantibodies induce a thrombotic complication in vivo is not understood. The classic assays for the detection of antiphospholipid antibodies (LAC and anticardiolipin ELISAs) aim to measure all the antiphospholipid antibodies present in the samples without making a distinction between the different subspecificities of the antibodies present in one single sample. Moreover, most of the in-vitro studies performed were carried our with total IgGs, which contain a mixture of antibodies. The absence of an accurate characterization of the plasma samples and the lack of specificity of the IgGs used in in-vitro teals makes it difficult to determine the contribution of antiprothrombin antibodies to the thrombotic complications. Here we review and critically analyse the literature regarding the clinical relevance of the presence of antiprothrombin antibodies and the possible participation of these antibodies in the pathogenesis of the thrombotic complications.
引用
收藏
页码:S32 / S36
页数:5
相关论文
共 36 条
[1]  
Arnout J, 1998, THROMB HAEMOSTASIS, V79, P79
[2]  
Arvieux J, 1996, THROMB HAEMOSTASIS, V75, P725
[3]   Circulating anti-(xanthine oxidoreductase) antibodies in healthy human adults [J].
Benboubetra, M ;
Gleeson, A ;
Harris, CPD ;
Khan, J ;
Arrar, L ;
Brennand, D ;
Reid, J ;
Reckless, JD ;
Harrison, R .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1997, 27 (07) :611-619
[4]  
BEVERS EM, 1991, THROMB HAEMOSTASIS, V66, P629
[5]   ANTIPHOSPHOLIPID ANTIBODIES - SPECIFICITY AND PATHOPHYSIOLOGY [J].
DEGROOT, PG ;
OOSTING, JD ;
DERKSEN, RHWM .
BAILLIERES CLINICAL HAEMATOLOGY, 1993, 6 (03) :691-709
[6]   AN UPDATE ON CLINICAL AND BASIC ASPECTS OF THE PROTEIN-C ANTICOAGULANT PATHWAY [J].
ESMON, CT ;
SCHWARZ, HP .
TRENDS IN CARDIOVASCULAR MEDICINE, 1995, 5 (04) :141-148
[7]   Pregnancy loss and autoantibodies against phospholipid-binding proteins [J].
Falcon, CR ;
Martinuzzo, ME ;
Forastiero, RR ;
Cerrato, GS ;
Carreras, LO .
OBSTETRICS AND GYNECOLOGY, 1997, 89 (06) :975-980
[8]  
Forastiero RR, 1997, THROMB HAEMOSTASIS, V78, P1008
[9]   KAOLIN CLOTTING TIME AND DILUTE RUSSELLS VIPER VENOM TIME DISTINGUISH BETWEEN PROTHROMBIN-DEPENDENT AND BETA-2-GLYCOPROTEIN I-DEPENDENT ANTIPHOSPHOLIPID ANTIBODIES [J].
GALLI, M ;
FINAZZI, G ;
BEVERS, EM ;
BARBUI, T .
BLOOD, 1995, 86 (02) :617-623
[10]   Differential effects of anti-β2-glycoprotein I and antiprothrombin antibodies on the anticoagulant activity of activated protein C [J].
Galli, M ;
Ruggeri, L ;
Barbui, T .
BLOOD, 1998, 91 (06) :1999-2004