Synthesis of fullerene glycoconjugates through sulfide connection in aqueous media

被引：41

作者：

Isobe, H ^{[1
]}

Mashima, H ^{[1
]}

Yorimitsu, H ^{[1
]}

Nakamura, E ^{[1
]}

机构：

[1] Univ Tokyo, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 23期

关键词：

D O I：

10.1021/ol0357705

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A thiolate/alkyl halide coupling reaction in aqueous media provides a one-step synthesis of fullerene glycoconjugates bearing five carbohydrate groups in good yield by using stoichiometric amounts of reactants, without recourse to hydroxy group protection. The sulfide-connection methodology is also useful for synthesis of simpler amphiphilic fullerene molecules, such as one bearing five carboxylic acid groups.

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收藏

页码：4461 / 4463

页数：3

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