Insecticide susceptibility and vector status of natural populations of Anopheles arabiensis from Sudan

被引：60

作者：

Abdalla, H. ^{[1
,2
,3
]}

Matambo, T. S. ^{[1
,2
]}

Koekemoer, L. L. ^{[1
,4
,5
]}

Mnzava, A. P. ^{[6
]}

Hunt, R. H. ^{[1
,2
]}

Coetzee, M. ^{[1
,4
,5
,6
]}

机构：

[1] NHLS, Natl Inst Communicable Dis, Vector Control Reference Unit, ZA-2131 Johannesburg, South Africa

[2] Univ Witwatersrand, Sch Anim Plant & Environm Sci, Johannesburg, South Africa

[3] Blue Nile Res & Training Inst, Wad Madani, Sudan

[4] Natl Hlth Lab Serv, Sch Pathol, Div Virol & Communicable Dis Surveillance, Johannesburg, South Africa

[5] Univ Witwatersrand, Johannesburg, South Africa

[6] World Hlth Org, Eastern Mediterranean Reg, Div Communicable Dis Control, Vector Biol & Control Programme, Cairo, Egypt

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2008年 / 102卷 / 03期

关键词：

anopheles arabiensis; insecticide resistance; kdr mutation; blood meals; sporozoite rate; Sudan;

D O I：

10.1016/j.trstmh.2007.10.008

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Species composition, blood meat source, sporozoite infection rate, insecticide resistance and the kdr mutations were investigated in the Anopheles gambiae complex from 13 sentinel. sites in central Sudan. Species identification revealed that 89.5% of 960 specimens were A. arabiensis. Of 310 indoor resting females, 88.1% were found to have fed on humans, while 10.6% had fed on bovines. The overall sporozoite infection rate from the five localities tested was 2.3%, ranging from 0 to 5.5%. Insecticide susceptibility bioassay results showed 100% mortality on bendiocarb, 54.6-94.2% on permethrin, 55.4-99.1% on DDT and 76.8-100% on malathion. The kdr analysis by PCR and sequencing revealed the presence of the Leu-Phe mutation in both permethrin and DDT bioassays. There was no significant difference in the frequency of kdr (P > 0.05) between dead and surviving specimens. These findings have serious implications for the malaria control programmes in Gezira and Sennar states. (c) 2007 Royal Society of Tropical, Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：263 / 271

页数：9

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