Chemogenomic approaches to drug discovery - Commentary

被引:129
作者
Caron, PR [1 ]
Mullican, MD [1 ]
Mashal, RD [1 ]
Wilson, KP [1 ]
Su, MS [1 ]
Murcko, MA [1 ]
机构
[1] Vertex Pharmaceut Inc, Cambridge, MA 02139 USA
关键词
D O I
10.1016/S1367-5931(00)00229-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:464 / 470
页数:7
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共 39 条
  • [1] Can we learn to distinguish between "drug-like" and "nondrug-like" molecules?
    Ajay
    Walters, WP
    Murcko, MA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (18) : 3314 - 3324
  • [2] Designing libraries with CNS activity
    Ajay
    Bemis, GW
    Murcko, MA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (24) : 4942 - 4951
  • [3] The properties of known drugs .1. Molecular frameworks
    Bemis, GW
    Murcko, MA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) : 2887 - 2893
  • [4] Properties of known drugs. 2. Side chains
    Bemis, GW
    Murcko, MA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (25) : 5095 - 5099
  • [5] Consensus scoring: A method for obtaining improved hit rates from docking databases of three-dimensional structures into proteins
    Charifson, PS
    Corkery, JJ
    Murcko, MA
    Walters, WP
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (25) : 5100 - 5109
  • [6] The development and therapeutic potential of protein kinase inhibitors
    Cohen, P
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (04) : 459 - 465
  • [7] The impact of genomics on drug discovery
    Debouck, C
    Metcalf, B
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2000, 40 : 193 - 207
  • [8] Interleukin-1β, interleukin-18, and the interleukin-1β converting enzyme
    Dinarello, CA
    [J]. MOLECULAR MECHANISMS OF FEVER, 1998, 856 : 1 - 11
  • [9] The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity
    Doyle, DA
    Cabral, JM
    Pfuetzner, RA
    Kuo, AL
    Gulbis, JM
    Cohen, SL
    Chait, BT
    MacKinnon, R
    [J]. SCIENCE, 1998, 280 (5360) : 69 - 77
  • [10] Drug discovery: A historical perspective
    Drews, J
    [J]. SCIENCE, 2000, 287 (5460) : 1960 - 1964