Replication and transcription: Shaping the landscape of the genome

被引：147

作者：

Chakalova, L ^{[1
]}

Debrand, E ^{[1
]}

Mitchell, JA ^{[1
]}

Osborne, CS ^{[1
]}

Fraser, P ^{[1
]}

机构：

[1] Babraham Inst, Lab Chromatin & Gene Express, Cambridge CB2 4AT, England

来源：

NATURE REVIEWS GENETICS | 2005年 / 6卷 / 09期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nrg1673

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

As the relationship between nuclear structure and function begins to unfold, a picture is emerging of a dynamic landscape that is centred on the two main processes that execute the regulated use and propagation of the genome. Rather than being subservient enzymatic activities, the replication and transcriptional machineries provide potent forces that organize the genome in three-dimensional nuclear space, Their activities provide opportunities for epigenetic changes that are required for differentiation and development. In addition, they impose physical constraints on the genome that might help to shape its evolution.

引用

页码：669 / 677

页数：9

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