Chelation of synaptic zinc induces overexcitation in the hilar mossy cells of the rat hippocampus

被引：31

作者：

Blasco-Ibáñez, JM ^{[1
]}

Poza-Aznar, J ^{[1
]}

Crespo, C ^{[1
]}

Marqués-Marí, AI ^{[1
]}

Gracia-Llanes, FJ ^{[1
]}

Martínez-Guijarro, FJ ^{[1
]}

机构：

[1] Univ Valencia, Fac Ciencias Biol, Dept Biol Celular, Neurobiol Unit, E-46100 Burjassot, Spain

来源：

NEUROSCIENCE LETTERS | 2004年 / 355卷 / 1-2期

关键词：

dietylditbiocarbarnate; heat shock protein; c-Fos; glutamate receptor; dentate gyrus; neural nuclear specific protein; commissural projections;

D O I：

10.1016/j.neulet.2003.10.053

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Complete removal of synaptic zinc by the chelator dietyldithiocarbamate (DEDTC; 500 mg/kg i.p.) in rat was followed by convulsive behaviour including wet dog shakes alternating immobility. Histological analysis 1 day after DEDTC administration detected expression of heat shock protein in the hippocampus restricted to hilar cells. These cells colocalize the marker for neurons and the glutamate receptor GluR2/3 showing that they are excitatory neurons. Additionally, they projected to the contralateral dentate gyrus. Therefore, they correspond to hilar mossy cells. These data show that the synaptic zinc has a role in normal hippocampus avoiding overexcitation, that would impair functionality even in absence of pathological or exoexcitotoxic phenomena. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：101 / 104

页数：4

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