Capillary zone electrophoresis as a potential technique for the simultaneous determination of sulfadoxine and pyrimethamine in tablet formulations

被引：17

作者：

Amin, N'Cho Christophe ^{[1
,2
]}

Blanchin, Marie-Dominique ^{[1
]}

Ake, Michele ^{[2
]}

Fabre, Huguette ^{[1
]}

机构：

[1] Inst Biomol Max Mousseron, Fac Pharm, UMR 5247, Chim Analyt Lab, F-34093 Montpellier, France

[2] Univ Cocody, UFR Sci Pharmaceut, Lab Chim Analyt Chim Minerale & Chim Gen, Abidjan, Cote Ivoire

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2012年 / 58卷

关键词：

Antimalarials; Sulfadoxine; Pyrimethamine; Tablets; Capillary zone electrophoresis; ANTIMALARIAL-DRUGS; HUMAN PLASMA; SULFONAMIDES; QUALITY; CHROMATOGRAPHY; MEFLOQUINE; SEPARATION; EXTRACTION; STACKING; RESIDUES;

D O I：

10.1016/j.jpba.2011.09.028

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

A novel, simple and rapid capillary zone electrophoresis method with UV detection has been developed for the simultaneous determination of pyrimethamine and sulfadoxine in tablet formulations. The compounds are separated in 6 min in a fused silica capillary, 30 cm long (20 cm to detector) x 50 mu m using a 100 mM phosphate buffer pH 7.2 as background electrolyte, a 330 V cm(-1) electric field and a detection wavelength of 214 nm. Analysis of different tablet formulations has shown a good agreement with the liquid chromatography method described in the United States Pharmacopoeia. Main advantages of the CZE method are the rapid set-up of instrumentation and capillary equilibration, short analysis time and low running cost. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：168 / 171

页数：4

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