Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp nov.

被引：71

作者：

Liu, R

Cui, CB

Duan, L

Gu, QQ ^{[1
]}

Zhu, WM

机构：

[1] Ocean Univ China, Inst Marine Drugs & Food, Qingdao 266003, Peoples R China

[2] Chinese Minist Educ, Key Lab Marine Drugs, Qingdao, Peoples R China

[3] AMMS, Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 12期

关键词：

Mycale plumose; sponge-derived actinomycete; Saccharopolyspora sp nov; metacycloprodigiosin; undecylprodigiosin; tripyrrole pigments; cytotoxicity;

D O I：

10.1007/BF02977899

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs - metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.

引用

页码：1341 / 1344

页数：4

共 9 条

[1]

Fürstner A, 2001, CHEMBIOCHEM, V2, P60

[2] Reversible and potent uncoupling of hog gastric (H++K+)-ATPase by prodigiosins [J].