The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

被引:328
作者
Gaeta, A [1 ]
Hider, RC [1 ]
机构
[1] Kings Coll London, Dept Pharm, London WC2R 2LS, England
关键词
neurodegeneration; protein aggregation; oxidative stress; A beta-amyloid; alpha-synuclein; prion protein; chelation therapy; iron; copper;
D O I
10.1038/sj.bjp.0706416
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review, Alzheimer's disease, Parkinson's disease and prion disease are discussed, with the aim of identifying common trends underlying these devastating neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.
引用
收藏
页码:1041 / 1059
页数:19
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