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A remarkable pyranose to furanose isomerization mediated by an "anomeric" silyloxy function

被引：9
作者：
Bhattacharya, SK
Chen, XT
Gutteridge, CE
Danishefsky, SJ
机构：
[1] Columbia Univ, Dept Chem, New York, NY 10027 USA
[2] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10021 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 17期
关键词：
antitumor compounds; eleutherobin; isomerization; rearrangements;
D O I：
10.1016/S0040-4039(99)00499-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The conversion of 3 to 6 is accomplished in high yields in three steps. The sequence greatly simplifies access to eleutherobin 1. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3313 / 3316
页数：4
相关论文
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Chen XT, 1998, ANGEW CHEM INT EDIT, V37, P789, DOI 10.1002/(SICI)1521-3773(19980403)37:6<789::AID-ANIE789>3.0.CO
[2]  
2-3
[3]  
Chen XT, 1998, ANGEW CHEM INT EDIT, V37, P185, DOI 10.1002/(SICI)1521-3773(19980202)37:1/2<185::AID-ANIE185>3.0.CO
[4]  
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ELIEL EL, 1994, STEREOCHEMISTRY ORGA, P791
[6]   Eleutherobin, a new cytotoxin that mimics paclitaxel (Taxol) by stabilizing microtubules [J].
Lindel, T ;
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Long, BH ;
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (37) :8744-8745
[7]  
Long BH, 1998, CANCER RES, V58, P1111
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