Phase variation affects long-term survival of Bordetella bronchiseptica in professional phagocytes

被引：30

作者：

Banemann, A ^{[1
]}

Gross, R ^{[1
]}

机构：

[1] UNIV WURZBURG,BIOZENTRUM,THEODOR BOVERI INST,LEHRSTUHL MIKROBIOL,D-97074 WURZBURG,GERMANY

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 08期

关键词：

D O I：

10.1128/IAI.65.8.3469-3473.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several Bordetella bronchiseptica isolates were investigated for intracellular survival in macrophages. A significant number of viable bacteria of all strains could be recovered even after 96 h postinfection, In all cases bvg mutants of the B. bronchiseptica strains showed a significant survival advantage over the respective wild-type strains. The bacteria were already located in phagolysosomes early after uptake, Neither opsonization of the bacteria nor activation of the macrophages with gamma interferon or lipopolysaccharide prior to infection affected uptake and survival of the bacteria.

引用

页码：3469 / 3473

页数：5

共 28 条

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