Prognostic significance of CA 125 and TPS levels after 3 chemotherapy courses in ovarian cancer patients

Objective. To evaluate the prognostic significance of and predictive value for survival of CA 125 and TPS levels after three chemotherapy courses in ovarian cancer patients. Methods. We analyzed in a prospective multicenter study the 1- and 2-year overall survival (OS) in ovarian carcinoma patients. The prognostic significance of CA 125 and TPS levels above the discrimination value (25 kU/L and 100 Un, respectively) was examined by univariate and multivariate analyses. Results. Of the 213 cases included, 64 patients were staged as PICO I + II and 149 patients were staged as PICO III + IV. Tumor marker levels in stage I + II were not correlated with survival. However, stage UI and IV patients with elevated levels of CA 125 or TPS after three chemotherapy courses had a worse 2-year OS (69% vs 26%, P < 0.0001 and 57% vs 20%, P < 0.0001, respectively) than patients with normal levels of the markers. In univariate analysis the result of operation (staging laparatomy and partial debulking) and advanced FIGO stage (IV) were also adverse prognostic factors. Independent factors predictive of low 2-year OS by multivariate analysis were staging laparotomy, TPS elevated, and CA 125 elevated, The only factors predictive of low 1-year OS were TPS elevated and staging laparotomy, Conclusions. Ovarian cancer patients with elevated CA 125 levels after three chemotherapy courses have a poor prognosis. Hoc-ever, the prognostic accuracy can be significantly increased by the parallel determination of serum TPS. (C) 2000 Academic Press.