Glucose-Responsive Insulinoma in a Patient with Postprandial Hypoglycemia in the Morning

被引:14
作者
Iida, Keiji [1 ]
Ohara, Takeshi [1 ]
Hino, Yasuhisa [1 ]
Nobuhara, Masahide [2 ]
Ishida, Jun [2 ]
Chihara, Kazuo [1 ]
机构
[1] Hyogo Prefectural Kakogawa Med Ctr, Div Diabet & Endocrinol, Kakogawa, Hyogo, Japan
[2] Hyogo Prefectural Kakogawa Med Ctr, Div Radiol, Kakogawa, Hyogo, Japan
关键词
insulinoma; hypoglycemia; postprandial; glucose; FUNCTIONING INSULINOMA; SECRETION;
D O I
10.2169/internalmedicine.49.3854
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report the case of an obese 79-year-old woman who experienced postprandial hypoglycemia in the morning. The serum immunoreactive insulin (IRI) and C-peptide levels responded in parallel with her serum glucose level during a 75-g oral glucose tolerance test. A prolonged fast test lowered her serum glucose level to 30 mg/dL, but serum IRI was not fully suppressed. Abdominal computed tomography revealed a tumor in the uncinate process of the pancreas. The tumor was histologically diagnosed as benign insulinoma after surgery. Therefore, glucose-responsive insulinoma as well as reactive hypoglycemia should be considered in patients who exhibit postprandial hypoglycemia.
引用
收藏
页码:2123 / 2127
页数:5
相关论文
共 20 条
[1]   GLUCOSE-TRANSPORTER PROTEINS IN HUMAN INSULINOMA [J].
BODEN, G ;
MURER, E ;
MOZZOLI, M .
ANNALS OF INTERNAL MEDICINE, 1994, 121 (02) :109-112
[2]  
Brun JF, 2000, DIABETES METAB, V26, P337
[3]   INSULINOMAS - LOCALIZATION WITH SELECTIVE INTRAARTERIAL INJECTION OF CALCIUM [J].
DOPPMAN, JL ;
MILLER, DL ;
CHANG, R ;
SHAWKER, TH ;
GORDEN, P ;
NORTON, JA .
RADIOLOGY, 1991, 178 (01) :237-241
[4]   Best Practice No 173 - Clinical and laboratory investigation of adult spontaneous hypoglycaemia [J].
Gama, R ;
Teale, JD ;
Marks, V .
JOURNAL OF CLINICAL PATHOLOGY, 2003, 56 (09) :641-646
[5]  
Harada Maya, 2010, Journal of the Japan Diabetes Society, V53, P626
[6]   REACTIVE HYPOGLYCEMIA [J].
HOFELDT, FD .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 1989, 18 (01) :185-201
[7]   Regulation of insulin secretion from novel engineered insulinoma cell lines [J].
Hohmeier, HE ;
BeltrandelRio, H ;
Clark, SA ;
HenkelRieger, R ;
Normington, K ;
Newgard, CB .
DIABETES, 1997, 46 (06) :968-977
[8]   Glucose-responsive and octreotide-sensitive insulinoma [J].
Izumiyama, Hajime ;
Gotyo, Naoki ;
Fukai, Nozomi ;
Ozawa, Naoko ;
Doi, Masaru ;
Yoshimoto, Takanobu ;
Arii, Sigeki ;
Hirata, Yukio .
INTERNAL MEDICINE, 2006, 45 (08) :519-524
[9]   INSULINOMA WITHOUT FASTING HYPOGLYCEMIA [J].
JORDAN, RM ;
KAMMER, H .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1976, 272 (02) :205-209
[10]   Clinical case seminar - Insulinomas may present with normoglycemia after prolonged fasting but glucose-stimulated hypoglycemia [J].
Kar, Partha ;
Price, Paul ;
Sawers, Stewart ;
Bhattacharya, Satya ;
Reznek, Rodney H. ;
Grossman, Ashley B. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (12) :4733-4736