How It's Made: The Synapse

被引：13

作者：

Bury, Luke A. D. ^{[1
]}

Sabo, Shasta L. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA

来源：

MOLECULAR INTERVENTIONS | 2010年 / 10卷 / 05期

关键词：

PRESYNAPTIC ACTIVE ZONE; RIM-BINDING PROTEINS; C-ELEGANS RPM-1; AXONAL-TRANSPORT; LIPRIN-ALPHA; NEUROTRANSMITTER RELEASE; EXCITATORY SYNAPSES; DENDRITIC FILOPODIA; CYTOPLASMIC DYNEIN; FORMATION REVEALS;

D O I：

10.1124/mi.10.5.5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

How are synapses made? This question is one of the most important issues in neurobiology today and has been the subject of intense study in recent years. This review focuses on the mechanisms of presynaptic terminal formation in the mammalian central nervous system. Building a synapse requires stabilization of contacts between axons and dendrites and formation of synaptic subcellular structures. Here, we discuss what determines where and when synapses form, how components of the nascent presynaptic terminal accumulate at the site of synapse formation, and whether assembly occurs via an ordered process dependent on a master organizer. Understanding synapse formation in the central nervous system is relevant for understanding and treating brain diseases as diverse as autism, epilepsy, anxiety disorders, brain injury, and Alzheimer's disease.

引用

页码：282 / 292

页数：11

共 110 条

[1]

Assembly of presynaptic active zones from cytoplasmic transport packets [J].

Ahmari, SE ;

Buchanan, J ;

Smith, SJ .

NATURE NEUROSCIENCE, 2000, 3 (05) :445-451

[2]

Linkers, packages and pathways: new concepts in axonal transport [J].

Almenar-Queralt, A ;

Goldstein, LSB .

CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (05) :550-557

[3]

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon [J].

Altrock, WD ;

Dieck, ST ;

Sokolov, M ;

Meyer, AC ;

Sigler, A ;

Brakebusch, C ;

Fässler, R ;

Richter, K ;

Boeckers, TM ;

Potschka, H ;

Brandt, C ;

Löscher, W ;

Grimberg, D ;

Dresbach, T ;

Hempelmann, A ;

Hassan, H ;

Balschun, D ;

Frey, JU ;

Brandstätter, JH ;

Garner, CC ;

Rosenmund, C ;

Gundelfinger, ED .

NEURON, 2003, 37 (05) :787-800

[4]

Actin and Microtubule-Based Cytoskeletal Cues Direct Polarized Targeting of Proteins in Neurons [J].

Arnold, Don B. .

SCIENCE SIGNALING, 2009, 2 (83)

[5]

Deletion of CASK in mice is lethal and impairs synaptic function [J].

Atasoy, Deniz ;

Schoch, Susanne ;

Ho, Angela ;

Nadasy, Krisztina A. ;

Liu, Xinran ;

Zhang, Weiqi ;

Mukherjee, Konark ;

Nosyreva, Elena D. ;

Fernandez-Chacon, Rafael ;

Missler, Markus ;

Kavalali, Ege T. ;

Suedhof, Thomas C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (07) :2525-2530

[6]

Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia [J].

Bailey, Craig H. ;

Kandel, Eric R. .

ESSENCE OF MEMORY, 2008, 169 :179-198

[7]

The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders [J].

Betancur, Catalina ;

Sakurai, Takeshi ;

Buxbaum, Joseph D. .

TRENDS IN NEUROSCIENCES, 2009, 32 (07) :402-412

[8]

SynCAM, a synaptic adhesion molecule that drives synapse assembly [J].

Biederer, T ;

Sara, Y ;

Mozhayeva, M ;

Atasoy, D ;

Liu, XR ;

Kavalali, ET ;

Südhof, TC .

SCIENCE, 2002, 297 (5586) :1525-1531

[9]

The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons [J].

Bloom, A. Joseph ;

Miller, Bradley R. ;

Sanes, Joshua R. ;

DiAntonio, Aaron .

GENES & DEVELOPMENT, 2007, 21 (20) :2593-2606

[10]

Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice [J].

Burgess, RW ;

Peterson, KA ;

Johnson, MJ ;

Roix, JJ ;

Welsh, IC ;

O'Brien, TP .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (03) :1096-1105

← 1 2 3 4 5 6 7 8 9 10 →