Matrix metalloproteinases in asthma and COPD

被引：133

作者：

Demedts, IK ^{[1
]}

Brusselle, GG ^{[1
]}

Bracke, KR ^{[1
]}

Vermaelen, KY ^{[1
]}

Pauwels, RA ^{[1
]}

机构：

[1] State Univ Ghent Hosp, Dept Resp Dis, B-9000 Ghent, Belgium

来源：

CURRENT OPINION IN PHARMACOLOGY | 2005年 / 5卷 / 03期

关键词：

D O I：

10.1016/j.coph.2004.12.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Asthma and chronic obstructive pulmonary disease (COPD) are both highly prevalent, chronic inflammatory lung diseases that lead to significant morbidity and mortality. Matrix metalloproteinases (MMPs) are extracellular matrix degrading enzymes that play a critical role in normal development and physiological tissue remodeling and repair. In addition, they play an important role in the regulation of the kinetics and function of inflammatory cells. There is increasing evidence that MMPs are involved in the pathogenesis of both asthma and COPD, and several MMPs are possible therapeutic targets in these common chronic airway diseases.

引用

页码：257 / 263

页数：7

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