Fitting and evaluating the glucose curve during a quasi continuous sampled oral glucose tolerance test

A dynamical model for blood glucose concentration, using a quasi continuous sample time interval OGTT is proposed. When this quasi continuous sample OGTT is performed, there are some detectable variations on blood glucose concentrations which could be related with reported endogenous glucose release. It is proposed that blood glucose concentration regulation system can be described by a number of linear, second order, underdamped subsystems, where blood glucose concentration dynamics can be viewed as a multifunction composed by the algebraic sum of the impulse responses of each subsystem, where unit impulse inputs are the glucose load, and the endogenous excitations. (C) 2007 Elsevier Ltd. All rights reserved.