Modulation effect of Semen Ziziphi Spinosae extracts on IL-1β, IL-4, IL-6, IL-10, TNF-α and IFN-γ in mouse serum

被引：57

作者：

Xie, Junbo ^{[1
]}

Guo, Li ^{[1
]}

Pang, Guangchang ^{[1
]}

Wu, Xin ^{[1
]}

Zhang, Mingchun ^{[1
]}

机构：

[1] Tianjin Univ Commerce, Coll Biotechnol & Food Sci, Tianjin Key Lab Food Biotechnol, Tianjin 300134, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2011年 / 25卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Semen Ziziphi Spinosae; hypnosis; IL-1; beta; IL-6; TNF-alpha; SLEEP; CYTOKINES; RATS; SYSTEM;

D O I：

10.1080/14786419.2010.534474

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

This study aims to explore and evaluate the effects of Semen Ziziphi Spinosae extracts on the serum levels of interleukin (IL)-6, IFN-gamma, IL-1 beta, TNF-alpha, IL-10 and IL-4 in mice, and the regulative effect of Semen Ziziphi Spinosae on the cytokine system. Using an ELISA assay, the serum levels of IL-6, IFN-gamma, IL-1 beta, TNF-alpha, IL-10 and IL-4 were examined in mice after intraperitoneal injection (i.p.) with Semen Ziziphi Spinosae extracts. The results showed that the levels of IL-6 and IL-1 beta were significantly increased compared with the control groups (p < 0.01), while the level of tumour necrosis factor-alpha (TNF-alpha) was significantly decreased (p < 0.01). Semen Ziziphi Spinosae possesses certain modulation effects on cytokines, and the immuno-regulating function and hypnosis effects of Semen Ziziphi Spinosae may be relevant to these modulation effects on cytokines.

引用

页码：464 / 467

页数：4

共 16 条

[1]

Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1β receptor 1 and tumor necrosis factor-α receptor 1 [J].