Buprenorphine and naloxone co-administration in opiate-dependent patients stabilized on sublingual buprenorphine

被引：97

作者：

Harris, DS

Jones, RT

Welm, S

Upton, RA

Lin, E

Mendelson, J

机构：

[1] Univ Calif San Francisco, Langley Porter Psychiat Inst, Drug Dependence Res Ctr, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA

来源：

DRUG AND ALCOHOL DEPENDENCE | 2000年 / 61卷 / 01期

关键词：

buprenorphine; naloxone; opiate withdrawal; sublingual; pharmacokinetics;

D O I：

10.1016/S0376-8716(00)00126-5

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Buprenorphine and naloxone sublingual (s.l.) dose formulations may decrease parenteral buprenorphine abuse. We evaluated pharmacologic interactions between 8 mg s.l. buprenorphine combined with 0, 4, or 8 mg of naloxone in nine opiate-dependent volunteers stabilized on 8 mg s.l. buprenorphine for 7 days. Combined naloxone and buprenorphine did not diminish buprenorphine's effects on opiate withdrawal nor alter buprenorphine bioavailability. Opiate addicts stabilized on buprenorphine showed no evidence of precipitated opiate withdrawal after s.l. buprenorphine-naloxone combinations. Buprenorphine and naloxone bioavailability was similar to 40 and 10%, respectively. Intravenous buprenorphine and naloxone produced subjective effects similar to those of s.l. buprenorphine and did not precipitate opiate withdrawal. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：85 / 94

页数：10

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