A highly stereoselective entry to α-hydroxy carboxylic acids using D-fructose diacetonide as a chiral auxiliary

被引：23

作者：

Yu, HW ^{[1
]}

Ballard, E ^{[1
]}

Wang, BH ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(01)00043-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protected alpha -hydroxy carboxylic acids were synthesized in moderate yield and high diastereoselectivity by alkylation of glycolate ester enolates using a D-fructose-derived chiral auxiliary. The new chiral center was assigned the (R)-configuration based upon comparisons to the literature. Both enantiomers of the auxiliary are readily available. (C) 2001 Published by Elsevier Science Ltd.

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页码：1835 / 1838

页数：4

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