New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and O139 Vibrio cholerae

被引：57

作者：

Silva, TMJ

Schleupner, MA

Tacket, CO

Steiner, TS

Kaper, JB

Edelman, R

Guerrant, RL

机构：

[1] UNIV VIRGINIA, SCH MED, DIV GEOG & INT MED, CHARLOTTESVILLE, VA 22908 USA

[2] UNIV MARYLAND, SCH MED, CTR VACCINE DEV, BALTIMORE, MD 21201 USA

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 06期

关键词：

D O I：

10.1128/IAI.64.6.2362-2364.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and O139 Vibrio cholerae strains. Data suggest that diarrhea due to attenuated and wild-type El Tor V. cholerae, and to a lesser extent O139 V. cholerae, involves an inflammatory response. Further study is required to further elucidate the mechanism of the process(es) involved.

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收藏

页码：2362 / 2364

页数：3

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