Isolation and sequence of the Drosophila virilis 60A gene, a transforming growth factor-beta superfamily member related to vertebrate bone morphogenetic proteins

被引：2

作者：

Du, W ^{[1
]}

Doctor, JS ^{[1
]}

机构：

[1] DUQUESNE UNIV, BAYER SCH NAT & ENVIRONM SCI, DEPT BIOL SCI, PITTSBURGH, PA 15282 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1996年 / 1307卷 / 03期

关键词：

transforming growth factor-beta superfamily; 60A gene; bone morphogenetic protein; (Drosophila);

D O I：

10.1016/0167-4781(96)00080-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complete protein-coding region of the Drosophila virilis 60A gene, a member of the transforming growth factor-beta superfamily, was isolated and sequenced. The mature domain of the protein-coding region is 99% identical to the Drosophila melanogaster 60A gene and 73% identical to human bone morphogenetic protein 5. In the pro-domain, a number of large blocks of amino acids are also highly conserved, indicating an important functional role for this portion of the protein as well. In the putative 5' and 3' untranslated regions, several short sequence motifs are conserved between D. virilis and D. melanogaster.

引用

页码：273 / 279

页数：7

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