Milking gene therapy

被引:7
作者
Alton, EWFW [1 ]
Griesenbach, U [1 ]
Geddes, DM [1 ]
机构
[1] Natl Heart & Lung Inst, Ion Transport Unit, London SW3 6LR, England
关键词
D O I
10.1038/2616
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oral administration of an adeno-associated virus vector that encodes the enzyme ß-galactosidase effectively reverses lactose intolerance in rats (pages 1131–1135).
引用
收藏
页码:1121 / 1122
页数:2
相关论文
共 12 条
[1]   Gene therapy for cystic fibrosis: Steady progress, should do well [J].
Alton, EWFW ;
Geddes, DM .
EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (02) :257-259
[2]  
Anderson WF, 1998, NATURE, V392, P25
[3]  
Balague C, 1997, J VIROL, V71, P3299
[4]   In vivo and in vitro gene transfer and expression in rat intestinal epithelial cells by E1-deleted adenoviral vector [J].
Cheng, DY ;
Kolls, JK ;
Lei, DH ;
Noel, RA .
HUMAN GENE THERAPY, 1997, 8 (06) :755-764
[5]  
Conrad CK, 1996, GENE THER, V3, P658
[6]  
CORAZZA GR, 1992, ALIMENT PHARM THERAP, V6, P61
[7]   Peroral gene therapy of lactose intolerance using an adeno-associated virus vector [J].
During, MJ ;
Xu, RL ;
Young, D ;
Kaplitt, MG ;
Sherwin, RS ;
Leone, P .
NATURE MEDICINE, 1998, 4 (10) :1131-1135
[8]   Transduction by adeno-associated virus vectors in the rabbit airway: Efficiency, persistence, and readministration [J].
Halbert, CL ;
Standaert, TA ;
Aitken, ML ;
Alexander, IE ;
Russell, DW ;
Miller, AD .
JOURNAL OF VIROLOGY, 1997, 71 (08) :5932-5941
[9]  
Hallek M, 1996, CYTOKINES MOL THER, V2, P69
[10]   Site-specific integration by adeno-associated virus [J].
Linden, RM ;
Ward, P ;
Giraud, C ;
Winocour, E ;
Berns, KI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :11288-11294