In vitro effects of photodynamic therapy on Aspergillus fumigatus

被引：68

作者：

Friedberg, JS

Skema, C

Baum, ED

Burdick, J

Vinogradov, SA

Wilson, DF

Horan, AD

Nachamkin, I

机构：

[1] Univ Penn, Sch Med, Dept Surg, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2001年 / 48卷 / 01期

关键词：

D O I：

10.1093/jac/48.1.105

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 X 10(1) cfu/mL with a light dose of 110 J/cm(2) and up to 2.7 X 10(6) cfu/mL with a light dose of 385 J/cm(2).

引用

页码：105 / 107

页数：3

共 10 条

[1] Fungicidal properties of meso-arylglycosylporphyrins:: influence of sugar substituents on photoinduced damage in the yeast Saccharomyces cerevisiae [J].