New 1α,25-dihydroxy vitamin D3 analogues with side chains attached to C-18:: Synthesis and biological activity

被引：10

作者：

Grue-Sorensen, G ^{[1
]}

Hansen, CM

机构：

[1] Leo Pharmaceut Prod, Dept Chem Res, DK-2750 Ballerup, Denmark

[2] Leo Pharmaceut Prod, Dept Biochem, DK-2750 Ballerup, Denmark

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 11期

关键词：

vitamins; antiproliferative agents;

D O I：

10.1016/S0968-0896(98)00161-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new class of analogues of 1 alpha,25-dihydroxy vitamin D-3 has been synthesised, in which the side chain (C-23 to C-27) has been removed and where new hydroxylated side chains have been attached to the C-18 methyl group. These analogues show antiproliferative activity in U937 and HaCaT cells comparable to that of 1 alpha,25-dihydroxy vitamin D-3. Lack of calcemic activity makes these analogues potentially useful in the treatment of proliferative diseases. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：2029 / 2039

页数：11

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