Enantioselective synthesis of alpha-phosphono sulfonate squalene synthase inhibitors: Chiral recognition in the interactions of an alpha-phosphono sulfonate inhibitor with squalene synthase

被引：36

作者：

Lawrence, RM

Biller, SA

Dickson, JK

Logan, JVH

Magnin, DR

Sulsky, RB

DiMarco, JD

Gougoutas, JZ

Beyer, BD

Taylor, SC

Lan, SJ

Ciosek, CP

Harrity, TW

Jolibois, KG

Kunselman, LK

Slusarchyk, DA

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,DIV DISCOVERY CHEM,PRINCETON,NJ 08543

[2] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,DEPT SOLID STATE CHEM,PRINCETON,NJ 08543

[3] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,ANALYT RES & DEV,PRINCETON,NJ 08543

[4] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,DEPT METAB & PHARMACOKINET,PRINCETON,NJ 08543

[5] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,DEPT METAB DIS,PRINCETON,NJ 08543

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1996年 / 118卷 / 46期

关键词：

D O I：

10.1021/ja962505o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：11668 / 11669

页数：2

共 19 条

[1] INHIBITORS OF SQUALENE BIOSYNTHESIS AND METABOLISM [J].

ABE, I ;

TOMESCH, JC ;

WATTANASIN, S ;

PRESTWICH, GD .

NATURAL PRODUCT REPORTS, 1994, 11 (03) :279-302

[2] MOLECULAR RECOGNITION IN BIOLOGICAL-SYSTEMS - PHOSPHATE-ESTERS VS SULFATE ESTERS AND THE MECHANISM OF ACTION OF STEROID SULFATASES [J].

ANDERSON, CJ ;

LUCAS, LJH ;

WIDLANSKI, TS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (13) :3889-3890

[3]

BENNANI YL, 1991, THESIS U MONTREAL

[4]

Biller SA, 1996, CURR PHARM DESIGN, V2, P1

[5] SYNTHESIS AND PROPERTIES OF A NONHYDROLYZABLE ADENOSINE PHOSPHOSULFATE ANALOG [J].

CALLAHAN, L ;

NG, K ;

GELLER, DH ;

AGARWAL, K ;

SCHWARTZ, NB .

ANALYTICAL BIOCHEMISTRY, 1989, 177 (01) :67-71

[6] SYNTHESIS OF ALPHA,BETA-UNSATURATED SULFONATES VIA THE WITTIG-HORNER REACTION [J].

CARRETERO, JC ;

DEMILLEQUAND, M ;

GHOSEZ, L .

TETRAHEDRON, 1987, 43 (21) :5125-5134

[7]

CHRISTENSEN BG, 1972, Patent No. 3657282

[8]

CIOSEK CP, 1993, J BIOL CHEM, V268, P24832

[9]

CROSSELY R, 1995, CHIRALITY BIOL ACTIV

[10] SOLUTION AND SOLID-STATE STRUCTURE OF A PHOSPHORUS-STABILIZED CARBANION [J].

DENMARK, SE ;

DOROW, RL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (02) :864-866

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