Evidence for progressive gray matter loss in patients with relapsing-remitting MS

被引：64

作者：

Valsasina, P

Benedetti, B

Rovaris, M

Sormani, MP

Comi, G

Filippi, M

机构：

[1] Univ H San Raffaele, Neuroimaging Res Unit, Dept Neurol, I-20132 Milan, Italy

[2] Univ H San Raffaele, Sci Inst, I-20132 Milan, Italy

[3] NCI, Clin Epidemiol Unit, Genoa, Italy

来源：

NEUROLOGY | 2005年 / 65卷 / 07期

关键词：

D O I：

10.1212/01.wnl.0000178982.53965.70

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Little is known about the temporal evolution of gray matter damage occurring early in the course of multiple sclerosis ( MS). The authors investigated the evolution of gray matter volume loss in 117 patients with relapsing-remitting MS, scanned monthly for a 9-month period. Time-trend analysis revealed a decrease of gray matter volumes over the study period (p < 0.001). This study shows that gray matter damage in relapsing-remitting MS evolves markedly over a short period of observation.

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收藏

页码：1126 / 1128

页数：3

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