Preparation of aryloxetanes and arylazetidines by use of an alkyl-aryl suzuki coupling

被引：67

作者：

Duncton, Matthew A. J. ^{[1
]}

Estiarte, M. Angels ^{[1
]}

Tan, Darlene ^{[1
]}

Kaub, Carl ^{[1
]}

O'Mahony, Donogh J. R. ^{[1
]}

Johnson, Russell J. ^{[1
]}

Cox, Matthew ^{[1
]}

Edwards, William T. ^{[1
]}

Wan, Min ^{[1
]}

Kincaid, John ^{[1
]}

Kelly, Michael G. ^{[1
]}

机构：

[1] Evotec USA, San Francisco, CA 94080 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 15期

关键词：

D O I：

10.1021/ol8011327

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The oxetan-3-yl and azetidin-3-yl substituents have previously been identified as privileged motifs within medicinal chemistry. An efficient approach to installing these two modules into aromatic systems, using a nickel-mediated alkyl-aryl Suzuki coupling, is presented.

引用

页码：3259 / 3262

页数：4

共 32 条

[1]

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