Targeting potential drivers of COVID-19: Neutrophil extracellular traps

被引：1119

作者：

Barnes, Betsy J. ^{[1
,2
,3
]}

Adrover, Jose M. ^{[4
]}

Baxter-Stoltzfus, Amelia ^{[5
]}

Borczuk, Alain ^{[5
]}

Cools-Lartigue, Jonathan ^{[6
]}

Crawford, James M. ^{[7
]}

Dassler-Plenker, Juliane ^{[4
]}

Guerci, Philippe ^{[8
]}

Huynh, Caroline ^{[6
,9
]}

Knight, Jason S. ^{[10
]}

Loda, Massimo ^{[5
]}

Looney, Mark R. ^{[11
]}

McAllister, Florencia ^{[12
]}

Rayes, Roni ^{[6
,9
]}

Renaud, Stephane ^{[8
]}

Rousseau, Simon ^{[13
,14
]}

Salvatore, Steven ^{[5
]}

Schwartz, Robert E. ^{[15
]}

Spicer, Jonathan D. ^{[6
,9
]}

Yost, Christian C. ^{[16
]}

Weber, Andrew ^{[17
]}

Zuo, Yu ^{[10
]}

Egeblad, Mikala ^{[4
]}

机构：

[1] Feinstein Inst Med Res, Ctr Autoimmune Musculoskeletal & Hematopoiet Dis, Hempstead, NY 11030 USA

[2] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Mol Med, Hempstead, NY 11549 USA

[3] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Pediat, Hempstead, NY 11549 USA

[4] Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA

[5] Weill Cornell Med, Dept Pathol & Lab Med, New York, NY USA

[6] Dept Surg, Div Thorac & Upper GI Surg, Montreal, PQ, Canada

[7] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Pathol & Lab Med, East Garden City, NY USA

[8] Ctr Hosp Univ Nancy, Nancy, France

[9] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ, Canada

[10] Univ Michigan, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA

[11] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[12] Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, Houston, TX 77030 USA

[13] McGill Univ, Dept Med, Montreal, PQ, Canada

[14] McGill Univ, Hlth Ctr, Res Inst, Montreal, PQ, Canada

[15] Weill Cornell Med, Div Gastroenterol & Hepatol, Dept Med, New York, NY USA

[16] Univ Utah, Sch Med, Dept Pediat, Program Mol Med, Salt Lake City, UT USA

[17] Northwell Hlth, Div Pulm Crit Care & Sleep Med, Dept Med, Manhasset, NY USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 06期

关键词：

CYTOKINE STORM; DNA TRAPS; HISTONES; PLATELETS; INJURY; INVOLVEMENT; ACTIVATION; CONTRIBUTE; THROMBOSIS; INITIATE;

D O I：

10.1084/jem.20200652

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in similar to 10-15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils-the ability to form neutrophil extracellular traps (NETs)-may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.

引用

页数：7

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