Antifungal activity of Agapanthus africanus extractives

被引：29

作者：

Singh, D. N. ^{[1
,2
]}

Verma, N. ^{[1
]}

Raghuwanshi, S. ^{[3
]}

Shukla, P. K. ^{[3
]}

Kulshreshtha, D. K. ^{[2
]}

机构：

[1] Dr Ram Manohar Lohia Avadh Univ, KS Saket PG Coll, Faizabad 224001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Proc & Med Chem Div, Lucknow 226001, Uttar Pradesh, India

[3] Cent Drug Res Inst, Fermentat Technol Div, Lucknow 226001, Uttar Pradesh, India

来源：

FITOTERAPIA | 2008年 / 79卷 / 04期

关键词：

Agapanthus africanus; spirostan saponin; antifungal activity;

D O I：

10.1016/j.fitote.2007.12.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The ethanolic extract of the rhizomes of Agapanthus africanus showed antifungal activity. In bioassay guided fractionation, n-butanol fraction exhibited significant activity against human pathogens. A saponin, (25R)-spirost-7-en-2 alpha,3 beta,5 alpha-triol-3-O-[alpha-L-rhamnopyranosyl(1 -> 2)-[beta-D-galactopyranosyl (1 -> 3)] beta-D-glucopyranoside (1), responsible for the antifungal activity and having MIC value of 15.6 mu g/ml against Trychophyton mentagrophytes and Sporothrix schenekii, was isolated and identified as active constituent of the plant. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：298 / 300

页数：3

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