Chemistry of zinc(II) fluorophore sensors

被引：133

作者：

Kimura, E ^{[1
]}

Aoki, S ^{[1
]}

机构：

[1] Hiroshima Univ, Fac Med, Dept Med Chem, Minami Ku, Hiroshima 7348551, Japan

来源：

BIOMETALS | 2001年 / 14卷 / 3-4期

关键词：

carbonic anhydrase; fluorophore; macrocyclic polyamine; sensor; sulfonamide; zinc; zinquin;

D O I：

10.1023/A:1012942511574

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The biological role of the zinc(II) ion has been recognized in DNA and RNA synthesis, apoptosis, gene expression, or protein structure and function. Therefore, development of useful zinc(II) sensors has recently been attracting much interest. Chemistry for selective and efficient detection of trace Zn2+ is a central issue. Recently, various types of zinc-fluorophores are emerging, comprising bio-inspired aromatic sulfonamide derivatives, zinc-finger peptides attached to fluorescent dyes, or fluorophore-pendant macrocyclic polyamines. The chemical principles, properties and limitations of these Zn2+-fluorophores are discussed.

引用

页码：191 / 204

页数：14

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