Effect of nicotine on hippocampal nicotinic acetylcholine α7 receptor and NMDA receptor subunits 2A and 2B expression in young and old rats

被引：28

作者：

Delibas, N

Doguc, DK

Sutcu, R

Eroglu, E

Gökalp, O

机构：

[1] Suleyman Demirel Univ, Fac Med, Dept Biochem, Isparta, Turkey

[2] Suleyman Demirel Univ, Fac Med, Dept Gen Surg, Isparta, Turkey

[3] Suleyman Demirel Univ, Fac Med, Dept Pharmacol, Isparta, Turkey

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2005年 / 115卷 / 08期

关键词：

hippocampus; lipid peroxidation; nAChR; nicotine; NMDAR;

D O I：

10.1080/00207450590914437

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Nicotinic acetylcholine (nAChR) and N-methyl-D-aspartate receptors (NMDARs) play critical roles in memory function. This study administered chronic nicotine to determine the alterations of N-methyl-D-aspartate receptor subunit 2A and 213 (NR2A, NR2B) and the alterations of alpha 7nAChR receptor. It was determined that the effectivity of nicotine and the data support that nicotine increases hippocampal NR2A and B expression. Additionally, the role of nicotine in the cognitive improvement was not supported by the antioxidative mechanisms or the authors observed no effect of nicotine on lipid peroxidation at the hippocampus.

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收藏

页码：1151 / 1163

页数：13

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