Formin-induced nucleation of actin filaments

被引：196

作者：

Zigmond, SH ^{[1
]}

机构：

[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 01期

关键词：

D O I：

10.1016/j.ceb.2003.10.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Formins are proteins best defined by the presence of the unique, highly conserved formin homology domain 2 (FH2). FH2 is necessary and sufficient to nucleate an actin filament in vitro. The FH2 domain also binds to the filament's barbed end, modulating its elongation and protecting it from capping proteins. FH2 itself appears to be a processive cap that walks with the barbed end as it elongates.

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页码：99 / 105

页数：7

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