Biocatalytic resolution of 2-methyl-2-(aryl)alkyloxiranes using novel bacterial epoxide hydrolases

被引：58

作者：

Osprian, I ^{[1
]}

Kroutil, W ^{[1
]}

Mischitz, M ^{[1
]}

Faber, K ^{[1
]}

机构：

[1] GRAZ UNIV TECHNOL,INST ORGAN CHEM,A-8010 GRAZ,AUSTRIA

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(96)00493-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Biocatalytic resolution of alkyl- and (arylalkyl)-oxiranes was accomplished by employing the epoxide hydrolase activity of lyophilized whole cells of seven bacterial strains belonging to the genera Rhodococcus, Mycobacterium and Nocardia. Whereas no suitable biocatalyst was found for 1-octene oxide, excellent selectivities were obtained with 2-methyl-2-substituted epoxides bearing an alkyl- or (aryl)alkyl side chain. (C) 1997, Elsevier Science Ltd. All rights reserved.

引用

页码：65 / 71

页数：7

共 39 条

[1]

Abraham W.-R., 1990, J ESSENT OIL RES, V2, P251, DOI [10.1080/10412905.1990.9697876, DOI 10.1080/10412905.1990.9697876]

[2] Carboxylation of epoxides to beta-keto acids in cell extracts of Xanthobacter strain Py2 [J].