Total synthesis of lucilactaene, a cell cycle inhibitor active in p53-inactive cells

被引：70

作者：

Coleman, RS ^{[1
]}

Walczak, MC ^{[1
]}

Campbell, EL ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 46期

关键词：

D O I：

10.1021/ja056217g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hetero-bis-metalated 1,3-butadiene is employed in the lynchpin coupling of synthetic fragments of the side chain of the antitumor agent, lucilactaene. Sequential Stille and Suzuki-Miyaura couplings interpolate this unique boron/tin diene into the pentaene chain. The total synthesis of lucilactaene was accomplished efficiently, in just eight linear steps. Copyright © 2005 American Chemical Society.

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页码：16038 / 16039

页数：2

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