Cell death: Shadow Baxing

被引:12
作者
Silke, J [1 ]
Vaux, DL [1 ]
机构
[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
关键词
D O I
10.1016/S0960-9822(07)00339-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bcl-2, one of a family of key regulators of apoptosis, was the first cell-death machinery component to be Identified, but how the family functions is still not clear. Mammalian Bar, a pro-apoptotic family member, can cause yeast cells to die, and two recent yeast genetic screens shed light: on how Bar might function.
引用
收藏
页码:R528 / R531
页数:4
相关论文
共 22 条
[1]   Inhibition of Bax channel-forming activity by Bcl-2 [J].
Antonsson, B ;
Conti, F ;
Ciavatta, A ;
Montessuit, S ;
Lewis, S ;
Martinou, I ;
Bernasconi, L ;
Bernard, A ;
Mermod, JJ ;
Mazzei, G ;
Maundrell, K ;
Gambale, F ;
Sadoul, R ;
Martinou, JC .
SCIENCE, 1997, 277 (5324) :370-372
[2]   GENETIC ISOLATION OF ADA2 - A POTENTIAL TRANSCRIPTIONAL ADAPTER REQUIRED FOR FUNCTION OF CERTAIN ACIDIC ACTIVATION DOMAINS [J].
BERGER, SL ;
PINA, B ;
SILVERMAN, N ;
MARCUS, GA ;
AGAPITE, J ;
REGIER, JL ;
TRIEZENBERG, SJ ;
GUARENTE, L .
CELL, 1992, 70 (02) :251-265
[3]   A CONSERVED DOMAIN IN BAK, DISTINCT FROM BH1 AND BH2, MEDIATES CELL-DEATH AND PROTEIN-BINDING FUNCTIONS [J].
CHITTENDEN, T ;
FLEMINGTON, C ;
HOUGHTON, AB ;
EBB, RG ;
GALLO, GJ ;
ELANGOVAN, B ;
CHINNADURAI, G ;
LUTZ, RJ .
EMBO JOURNAL, 1995, 14 (22) :5589-5596
[4]   The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4 [J].
Huang, DCS ;
Adams, JM ;
Cory, S .
EMBO JOURNAL, 1998, 17 (04) :1029-1039
[5]  
INK E, 1997, MOL CELL BIOL, V17, P2488
[6]   BAX-DEFICIENT MICE WITH LYMPHOID HYPERPLASIA AND MALE GERM-CELL DEATH [J].
KNUDSON, CM ;
TUNG, KSK ;
TOURTELLOTTE, WG ;
BROWN, GAJ ;
KORSMEYER, SJ .
SCIENCE, 1995, 270 (5233) :96-99
[7]   Cell-specific induction of apoptosis by microinjection of cytochrome c - Bcl-x(L) has activity independent of cytochrome c release [J].
Li, F ;
Srinivasan, A ;
Wang, Y ;
Armstrong, RC ;
Tomaselli, KJ ;
Fritz, LC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (48) :30299-30305
[8]   Release of cytochrome c and decrease of cytochrome c oxidase in Bax-expressing yeast cells, and prevention of these effects by coexpression of Bcl-x(L) [J].
Manon, S ;
Chaudhuri, B ;
Guerin, M .
FEBS LETTERS, 1997, 415 (01) :29-32
[9]   The mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells [J].
Matsuyama, S ;
Xu, QL ;
Velours, J ;
Reed, JC .
MOLECULAR CELL, 1998, 1 (03) :327-336
[10]   X-ray and NMR structure of human Bcl-x(L), an inhibitor of programmed cell death [J].
Muchmore, SW ;
Sattler, M ;
Liang, H ;
Meadows, RP ;
Harlan, JE ;
Yoon, HS ;
Nettesheim, D ;
Chang, BS ;
Thompson, CB ;
Wong, SL ;
Ng, SC ;
Fesik, SW .
NATURE, 1996, 381 (6580) :335-341