Dapagliflozin reduces albuminuria over 2 years in patients with type 2 diabetes mellitus and renal impairment

被引:107
作者
Fioretto, Paola [1 ]
Stefansson, Bergur V. [2 ]
Johnsson, Eva [2 ]
Cain, Valerie A. [3 ]
Sjostrom, C. David [2 ]
机构
[1] Univ Padua, Dept Med, Clin Med 3, Via Giustiniani 2, I-35128 Padua, Italy
[2] AstraZeneca, Molndal, Sweden
[3] AstraZeneca, Wilmington, DE USA
关键词
Albuminuria; Dapagliflozin; Renal impairment; SGLT2; inhibition; Type; 2; diabetes; BLOOD-PRESSURE;
D O I
10.1007/s00125-016-4017-1
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
引用
收藏
页码:2036 / 2039
页数:4
相关论文
共 6 条
[1]
Sodium/Glucose Cotransporter 2 Inhibitors and Prevention of Diabetic Nephropathy: Targeting the Renal Tubule in Diabetes [J].
De Nicola, Luca ;
Gabbai, Francis B. ;
Liberti, Maria Elena ;
Sagliocca, Adelia ;
Conte, Giuseppe ;
Minutolo, Roberto .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2014, 64 (01) :16-24
[2]
Galectin-3, Renal Function, and Clinical Outcomes: Results from the LURIC and 4D Studies [J].
Drechsler, Christiane ;
Delgado, Graciela ;
Wanner, Christoph ;
Blouin, Katja ;
Pilz, Stefan ;
Tomaschitz, Andreas ;
Kleber, Marcus E. ;
Dressel, Alexander ;
Willmes, Christoph ;
Krane, Vera ;
Kraemer, Bernhard K. ;
Maerz, Winfried ;
Ritz, Eberhard ;
van Gilst, Wiek H. ;
van der Harst, Pim ;
de Boer, Rudolf A. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 26 (09) :2213-2221
[3]
Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiotensin blockers [J].
Heerspink, H. J. L. ;
Johnsson, E. ;
Gause-Nilsson, I. ;
Cain, V. A. ;
Sjostrom, C. D. .
DIABETES OBESITY & METABOLISM, 2016, 18 (06) :590-597
[4]
Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control [J].
Kohan, Donald E. ;
Fioretto, Paola ;
Tang, Weihua ;
List, James F. .
KIDNEY INTERNATIONAL, 2014, 85 (04) :962-971
[5]
Sodium glucose cotransporter 2 and the diabetic kidney [J].
Komala, Muralikrishna Gangadharan ;
Panchapakesan, Usha ;
Pollock, Carol ;
Mather, Amanda .
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2013, 22 (01) :113-119
[6]
Mortality and morbidity in relation to changes in albuminuria, glucose status and systolic blood pressure: an analysis of the ONTARGET and TRANSCEND studies [J].
Schmieder, Roland E. ;
Schutte, Rudolph ;
Schumacher, Helmut ;
Boehm, Michael ;
Mancia, Giuseppe ;
Weber, Michael A. ;
McQueen, Matthew ;
Teo, Koon ;
Yusuf, Salim .
DIABETOLOGIA, 2014, 57 (10) :2019-2029